All Things Peptides — Interactive Wiki

Self-contained reference: mechanisms, PK, dosing patterns, timelines, blends, caveats. Non-medical. For education only.

Summary Table — Compounds

Click a header to sort. Click a compound to jump to its section.
Compound Type / Mechanism Status Typical Dosing Pattern Half-life Onset Window Highlights Notes

Summary Table — Popular Blends

Marketing names vary by clinic/vendor; verify exact ingredients.
Blend Components Rationale / Use Notes

PK & Dosing Explorer (First-Order Accumulation)

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Toy model to visualize accumulation with half-life dosing. Assumes linear PK and instant absorption. For education only.
Tip: For 5-on/2-off, use daily interval and imagine no doses on days 6–7 each week (the preset approximates by zeroing weekend doses).

Jump To Compound

Mixing & Dilution Cautions

Important

Finished, labeled products (e.g., Zepbound® tirzepatide) are formulated with specific buffers, tonicity, and sterile handling. **Do not dilute or co-mix** finished products unless the label explicitly instructs it. Stability, dosing accuracy, sterility, and immunogenicity risks increase when altering formulation.

Formulation facts (illustrative)

Tirzepatide (Zepbound®)

Aqueous solution with sodium phosphate buffer; pH typically ~6.5–7.5. Single-dose pens.

Bacteriostatic Water (USP)

Sterile water with preservative (benzyl alcohol). pH commonly around ~5.7 (range ~4.5–7.0). Not a buffer.

Because Zepbound is **buffered**, adding small volumes of mildly acidic diluent won’t shift pH much — but it **will** violate labeled use, may change adsorption/aggregation behavior, and compromises sterility in a device not designed for multi-dose withdrawal. Use lower strengths or prescriber-directed compounded vials rather than ad‑hoc dilution.

Glossary & Concepts

GHRH vs GHRP (GHSR agonists)

GHRH analogs (e.g., sermorelin, CJC-1295) stimulate pituitary GH release via the GHRH receptor; GHRPs (e.g., ipamorelin) stimulate via the ghrelin receptor (GHSR). Stacking them can yield larger, more physiologic pulses.

Somatostatin negative feedback

When GH/IGF-1 rise, somatostatin increases and suppresses further GH release, putting a natural brake on short-acting GHRH analogs like sermorelin.

DAC (Drug Affinity Complex)

A modification used with CJC-1295 to bind albumin, extending half-life from minutes to days, creating a tonic GH drive rather than short pulses.

Pulsatile vs tonic exposure

Short-acting stacks (Mod‑GRF + ipamorelin) create brief GH spikes that mimic physiology; long-acting (CJC‑DAC) raises baseline exposure for convenience but may increase side-effect risk if overdone.

Incretins (GLP‑1/GIP) & Half-life

Semaglutide (~7 d), tirzepatide (~5–6 d), retatrutide (~6 d, investigational) are long-acting once‑weekly agents. Micro‑patterns mainly change peak/trough swing—total weekly mg determines average exposure.

Disclaimer: Educational content. Not medical advice. Many items here are investigational or not FDA‑approved. Consult a licensed clinician before use.